Pharmacology and toxicology of dihydroartemisinin tablets

Pharmacology: This product is an artemisinin derivative that has a potent and rapid killing effect on the erythrocyte phase of Plasmodium and can quickly control clinical attacks and symptoms. The mechanism of action of artemisinin is not very clear, which mainly affects the mitochondrial function of Plasmodium surface membranes. Artemisinin changes the structure of the Plasmodium membrane, affecting the ultrastructure of its erythrocyte phase. Due to its effect on the food vesicles, the absorption of nutrients by Plasmodium is blocked, resulting in the loss of large amounts of Plasmodium cytoplasm and nutrients, as well as a lack of supplements, resulting in the rapid death of Plasmodium. The mechanism of action is mediated by free iron produced by the decomposition of hemoglobin through its internal peroxide (dioxygen) bridge, which produces unstable organic free radicals and/or other electrophilic mediators and then forms covalent adducts with Plasmodium proteins, resulting in the death of Plasmodium. The antimalarial activity of artemether was 6 times higher than that of artemisinin. Toxicology: Animal reproductive toxicity studies have proven that administration during pregnancy induction in mice can increase embryo absorption but does not have a teratogenic effect.