Paracetamol (acetaminophen)
Paracetamol (acetaminophen) is used as an antipyretic, analgesic and antirheumatic agent. It is the most commonly used non-anti-inflammatory, antipyretic and analgesic drug. Its antipyretic effect is similar to that of aspirin. The analgesic effect is weak and does not have anti-inflammatory or antirheumatic effects. This is the best type of acetanilide drugs. This is especially suitable for patients who cannot use carboxylic acid preparations. For colds, toothache, etc.
Description
1.Physico-chemical properties of paracetamol (acetaminophen)
| CAS | 103-90-2 |
| EINEX | 203-157-5 |
| chemical formula | C8H9O2 |
| molecular weight | 151.16 |
| InCHI | InChI=1/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10) /i2D, 3D, 4D, 5D |
| melting temperature | 168-172 degrees |
| Boiling point | 387.8 degrees at 760 mm Hg. |
| Water solubility | 14 g/l (20 degrees) |
| solubility | Easily soluble in hot water or ethanol, soluble in acetone, almost insoluble in cold water and petroleum ether. |
| Refractive index | 1.619 |
2.Statement:
Paracetamol is a widely used analgesic that is mainly used for colds, toothache and other diseases. It can also relieve joint pain and migraines caused by the common cold. Moreover, it is also suitable for relieving mild to moderate pain such as fever, dysmenorrhea, etc.

Paracetamol ((acetaminophen) is a kind of antipyretic and analgesic drug with a certain therapeutic effect and fewer side effects. At present, paracetamol has become one of the most widely used drugs in the world, is the number one antipyretic and analgesic drug in the world pharmaceutical market, and is also one of the largest API manufacturers in China.

3. COA of paracetamol (acetaminophen)
|
Test tasks |
Standard |
Test result |
|
Characteristics |
White or almost white crystalline powder |
Correspond |
|
Identification |
A. Melting point: 168~172.0degree |
169.5~170.5degree |
|
C.IR: according to spectrum |
Correspond |
|
|
Related substances |
Impurity J (chloroacetanilideLess or equal0.001 percent ) |
0 |
|
Impurity K (4-aminophenolLess or equal0.005 percent ) |
5.10 ppm |
|
|
Impurity F (4-nitrophenolLess or equal0.05 percent ) |
0 |
|
|
Any other impurityLess or equal0.05 percent |
0.02 percent |
|
|
Total other impuritiesLess or equal0.1 percent |
00.03 percent |
|
|
Damage due to drying out |
Less or equal0.5 percent |
0.17 percent |
|
Ignition residue |
Less or equal0.1 percent |
0.03 percent |
|
analysis |
99.0-101.0 percent (based on dry weight) |
99.5 percent |
|
Conclusion: |
The above product complies with BP2018/USP42 standard. |
|
4.Advantages of TNN
TNN DEVELOPMENT LIMITED is a trading company with 32 employees; it was founded in 1998, located in room 2901, 2902, 2908, Hongyuan Building, No. 23, Renmin Road, Zhongshan District, Dalian, Liaoning, China. The offices occupy an area of 485 square meters. TNN DEVELOPMENT LIMITED has its own brand. They have passed ISO9001:2015 certification. THE TNN DEVELOPMENT LIMITED has successful foreign trade experience in North America, South America, Europe, Africa, Australia and Asia.

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